Back to search

Peptide record

TPDB30536

Neurotoxin Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB30536
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ERVCCGYPMSCKSRACKPSYCC
Physicochemical Analysis
C99H160N30O30S7
NDQHILFTW
C
2474.96
8.31
4
1
5
+3
3.27
-0.273
17.73
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
3355
135.56
11
Residue Composition
number
1
A
2
R
0
N
0
D
6
C
1
E
0
Q
1
G
0
H
0
I
0
L
2
K
1
M
0
F
2
P
3
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 6 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 1 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
22
C99H160N30O30S7
2474.96
8.31
+3
3.27
-0.273
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav) (By similarity). Intraperitoneal injection into fish (1 nmol) provokes weakening and difficulty in swimming after 20 minutes. {ECO:0000250, ECO:0000269|PubMed:20570703}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus parius (Cone snail)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav) (By similarity). Intraperitoneal injection into fish (1 nmol) provokes weakening and difficulty in swimming after 20 minutes..
Mu-conotoxin-like pr3b
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin-like pr3b
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail