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Peptide record

TPDB30500

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB30500
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ERGLPEGAECDGNESDCKCAGAWIKCRCPPMWHING
Physicochemical Analysis
C163H250N50O52S6
QFTYV
CG
3934.44
4.81
5
6
9
-2
10.65
-0.689
40.83
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
11250
285.94
8
Residue Composition
number
3
A
2
R
2
N
2
D
5
C
4
E
0
Q
5
G
1
H
2
I
1
L
2
K
1
M
0
F
3
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 2 C: 5 E: 4 Q: 0 G: 5 H: 1 I: 2 L: 1 K: 2 M: 1 F: 0 P: 3 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
36
C163H250N50O52S6
3934.44
4.81
-2
10.65
-0.689
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. This toxin is a blocker of L-type calcium channels (Cav/CACNA1).

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically.
Omega-agatoxin-Aa1b (Omega-AGTX-Aa1b) (Omega-agatoxin IB) (Omega-Aga-IB) (Omega-agatoxin-1B)
spider
Neurotoxin 04 (omega-agtx) family, 01 (type I omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 01 (type I omega-agtx) subfamily
Omega-agatoxin-Aa1b (Omega-AGTX-Aa1b) (Omega-agatoxin IB) (Omega-Aga-IB) (Omega-agatoxin-1B)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider