Back to search

Peptide record

TPDB30498

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB30498
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ERDSCVEKSKCGKYGYYGQCDECCKKAGDRAGTCVYYKCKCNP
Physicochemical Analysis
C200H312N58O66S8
HILMFW
C
4841.51
8.08
9
6
9
+3
13.38
-1.040
18.14
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
7950
164.21
18
Residue Composition
number
2
A
2
R
1
N
3
D
8
C
3
E
1
Q
5
G
0
H
0
I
0
L
7
K
0
M
0
F
1
P
2
S
1
T
0
W
5
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 3 C: 8 E: 3 Q: 1 G: 5 H: 0 I: 0 L: 0 K: 7 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 5 V: 2
Chemical Descriptors
43
C200H312N58O66S8
4841.51
8.08
+3
13.38
-1.040
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks Kv11/ERG potassium channels. Is less toxic than ergtoxin (AC Q86QT3). {ECO:0000269|PubMed:12076661}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides sculpturatus (Arizona bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly blocks Kv11/ERG potassium channels. Is less toxic than ergtoxin (AC Q86QT3)..
Potassium channel toxin gamma-KTx 4.12 (CsEKerg1)
scorpion
Ergtoxin family, Gamma-KTx 4 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 4 subfamily
Potassium channel toxin gamma-KTx 4.12 (CsEKerg1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion