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Peptide record

TPDB30420

Neurotoxin Toxicity standard
74 amino acids
Basic Information
3D PDB MODEL
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TPDB30420
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 74-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
EIAQNLGSGIPHIRTKLPNGQWCKTPGDLCSSRSECCKAEDSVTYSSGCSRQWSGQQGTFINQCRTCNVESSMC
Physicochemical Analysis
C331H527N103O114S9
S
8061.99
7.50
8
6
16
+1
15.38
-0.619
47.43
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
12990
161.13
35
Residue Composition
number
2
A
4
R
4
N
2
D
8
C
4
E
6
Q
7
G
1
H
4
I
3
L
3
K
1
M
1
F
3
P
11
S
5
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 4 N: 4 D: 2 C: 8 E: 4 Q: 6 G: 7 H: 1 I: 4 L: 3 K: 3 M: 1 F: 1 P: 3 S: 11 T: 5 W: 2 Y: 1 V: 2
Chemical Descriptors
74
C331H527N103O114S9
8061.99
7.50
+1
15.38
-0.619
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin with probable ion channel impairing activity. In vivo, is both paralytic and lethal, when injected into lepidopteran larvae. {ECO:0000269|PubMed:1440641}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Apomastus schlingeri (Trap-door spider) (Aptostichus schlingeri)
Neurotoxin Ion channel impairing toxin
Neurotoxin with probable ion channel impairing activity. In vivo, is both paralytic and lethal, when injected into lepidopteran larvae..
U1-cyrtautoxin-As1a (U1-CUTX-As1a) (Aptotoxin I) (Aptotoxin-1) (Paralytic peptide I) (PP I)
spider
Neurotoxin 21 family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1440641}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 21 family
U1-cyrtautoxin-As1a (U1-CUTX-As1a) (Aptotoxin I) (Aptotoxin-1) (Paralytic peptide I) (PP I)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:1440641}.
spider