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Peptide record

TPDB30377

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB30377
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
EDGYLLNRDTGCKVSCGTCRYCND
Physicochemical Analysis
C107H169N33O40S4
AQHIMFPW
C
2685.96
4.45
3
4
5
-1
5.71
-0.754
44.58
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
3230
120.26
11
Residue Composition
number
0
A
2
R
2
N
3
D
4
C
1
E
0
Q
3
G
0
H
0
I
2
L
1
K
0
M
0
F
0
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 3 C: 4 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
24
C107H169N33O40S4
2685.96
4.45
-1
5.71
-0.754
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.
Neurotoxin-2 (BT-II) (Neurotoxin II)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Neurotoxin-2 (BT-II) (Neurotoxin II)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion