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Peptide record

TPDB30374

Neurotoxin Toxicity standard
62 amino acids
Basic Information
3D PDB MODEL
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TPDB30374
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 62-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
EDEVEETLPVAEEGREKSCITWRNSCVHNDKGCCFPWSCVCWSQTVSRNSSRKEKKCQCRLW
Physicochemical Analysis
C306H477N93O98S8
MY
CE
7283.20
6.72
11
10
14
-0
21.55
-0.892
43.87
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
22500
308.93
23
Residue Composition
number
1
A
5
R
3
N
2
D
8
C
8
E
2
Q
2
G
1
H
1
I
2
L
5
K
0
M
1
F
2
P
7
S
3
T
4
W
0
Y
5
V
Amino Acid Distribution
A: 1 R: 5 N: 3 D: 2 C: 8 E: 8 Q: 2 G: 2 H: 1 I: 1 L: 2 K: 5 M: 0 F: 1 P: 2 S: 7 T: 3 W: 4 Y: 0 V: 5
Chemical Descriptors
62
C306H477N93O98S8
7283.20
6.72
-0
21.55
-0.892
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons (By similarity). At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (By similarity). In vivo, does not cause death when intravenously injected into mice (By similarity). In rat models, through its activity on Cav2.1/CACNA1A, has an ameliorative effect on memory defects provoked by hyperstimulation of N-methyl-D-aspartate receptors (NMDARs) in the hippocampus (By similarity). {ECO:0000250|UniProtKB:P0DRA9, ECO:0000250|UniProtKB:P85079}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Alopecosa marikovskyi (Wolf spider) (Lycosa kazakhstanicus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Modulates Cav2.1/CACNA1A voltage-gated calcium channels (P/Q-type currents) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons (By similarity). At saturating concentrations (>10 nM) decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics (By similarity).
Omega-lycotoxin-Am1e (Omega-LCTX-Am1e) (Omega-Lsp-IA-like 6) (Omega-lycotoxin-Gsp(267)1e) (Omega-LCTX-Gsp(267)1e)
spider
Neurotoxin omega-lctx family
Evidence at transcript level
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17888477}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at transcript level
Neurotoxin omega-lctx family
Omega-lycotoxin-Am1e (Omega-LCTX-Am1e) (Omega-Lsp-IA-like 6) (Omega-lycotoxin-Gsp(267)1e) (Omega-LCTX-Gsp(267)1e)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17888477}.
spider