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Peptide record

TPDB30353

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB30353
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
EDCIAVGQLCVFWNIGRPCCSGLCVFACTVKLP
Physicochemical Analysis
C156H246N40O42S6
HMY
C
3546.27
5.97
2
2
14
-0
-0.66
0.976
100.30
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5875
165.67
10
Residue Composition
number
2
A
1
R
1
N
1
D
6
C
1
E
1
Q
3
G
0
H
2
I
3
L
1
K
0
M
2
F
2
P
1
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 3 K: 1 M: 0 F: 2 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
33
C156H246N40O42S6
3546.27
5.97
-0
-0.66
0.976
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav) (By similarity). Has strong insecticidal properties at a dose of only 100 pmol/g of body weight (when injected into the haemocoel of the wax moth G.mellonella larvae). Provoques tremor and uncontrolled movements in insect larvae, that are typical symptoms caused by neurotoxins (PubMed:22728460). On fish G.niger, intraperitoneal injection of the toxin causes full extension of the fins, change in posture, breathing difficulties (at 30 and 100 pmol/g body weight) and death (at 100 pmol/g body weight) (PubMed:22728460). {ECO:0000250, ECO:0000269|PubMed:22728460}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ventricosus (Mediterranean cone)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav) (By similarity). Has strong insecticidal properties at a dose of only 100 pmol/g of body weight (when injected into the haemocoel of the wax moth G.mellonella larvae).
Omega-conotoxin-like Vn2 (Conotoxin Vn2) (Conotoxin-Vn) (Vn6A)
cone snail
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 6 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Omega-conotoxin-like Vn2 (Conotoxin Vn2) (Conotoxin-Vn) (Vn6A)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail