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Peptide record

TPDB30345

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB30345
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ECVPENGHCRDWYDECCEGFYCSCRQPPKCICRNNN
Physicochemical Analysis
C174H256N54O57S8
ALMT
C
4272.75
4.81
5
6
6
-2
11.66
-1.042
18.89
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
8980
210.17
16
Residue Composition
number
0
A
3
R
4
N
2
D
8
C
4
E
1
Q
2
G
1
H
1
I
0
L
1
K
0
M
1
F
3
P
1
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 4 D: 2 C: 8 E: 4 Q: 1 G: 2 H: 1 I: 1 L: 0 K: 1 M: 0 F: 1 P: 3 S: 1 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
36
C174H256N54O57S8
4272.75
4.81
-2
11.66
-1.042
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2914898}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Aa1a (Mu-AGTX-Aa1a) (Mu-agatoxin I) (Mu-agatoxin-1)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 04 (aga-5) subfamily
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 04 (aga-5) subfamily
Mu-agatoxin-Aa1a (Mu-AGTX-Aa1a) (Mu-agatoxin I) (Mu-agatoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
spider