Back to search

Peptide record

TPDB30288

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB30288
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECGTLFSGCSTHADCCEGFICKLWCRYERTW
Physicochemical Analysis
C155H226N42O46S6
NQMPV
C
3606.11
5.42
4
4
9
-1
1.63
-0.116
40.97
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
12865
356.76
12
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
3
E
0
Q
3
G
1
H
1
I
2
L
1
K
0
M
2
F
0
P
2
S
3
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 3 Q: 0 G: 3 H: 1 I: 1 L: 2 K: 1 M: 0 F: 2 P: 0 S: 2 T: 3 W: 2 Y: 1 V: 0
Chemical Descriptors
31
C155H226N42O46S6
3606.11
5.42
-1
1.63
-0.116
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks transient outward voltage-gated potassium channels in rat ventricular myocytes (thus prolonging action-potential duration) and rat Kv4.2/KCNA4 channels expressed in Xenopus oocytes. Is also a weak blocker of calcium channels in rat cerebellar granule cells. {ECO:0000269|PubMed:9058605, ECO:0000269|Ref.2}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks transient outward voltage-gated potassium channels in rat ventricular myocytes (thus prolonging action-potential duration) and rat Kv4.2/KCNA4 channels expressed in Xenopus oocytes. Is also a weak blocker of calcium channels in rat cerebellar granule cells..
Kappa-sparatoxin-Hv1c (Kappa-SPRTX-Hv1c) (Heteropodatoxin-3) (HpTX3) (Toxin AU5C/KJ7)
spider
Neurotoxin 10 (Hwtx-1) family, 20 (HpTX3) subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9058605, ECO:0000305|Ref.2}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 20 (HpTX3) subfamily
Kappa-sparatoxin-Hv1c (Kappa-SPRTX-Hv1c) (Heteropodatoxin-3) (HpTX3) (Toxin AU5C/KJ7)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9058605, ECO:0000305|Ref.2}.
spider