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Peptide record

TPDB30261

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB30261
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECCNPACGRHYSCGK
Physicochemical Analysis
C63H98N22O21S4
DQILMFTWV
C
1627.85
7.85
3
1
2
+1
3.73
-0.753
6.67
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1740
106.89
7
Residue Composition
number
1
A
1
R
1
N
0
D
4
C
1
E
0
Q
2
G
1
H
0
I
0
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 0 C: 4 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C63H98N22O21S4
1627.85
7.85
+1
3.73
-0.753
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus geographus (Geography cone) (Nubecula geographus)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
Alpha-conotoxin GIA
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:7014556}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin GIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:7014556}.
cone snail