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Peptide record

TPDB30240

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB30240
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ECATKNKRCADWAGPWCCDGLYCSCRSYPGCMCRPSS
Physicochemical Analysis
C168H255N51O52S9
QHIFV
C
4109.72
7.84
5
3
9
+2
2.55
-0.500
18.65
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
14480
352.34
16
Residue Composition
number
3
A
3
R
1
N
2
D
8
C
1
E
0
Q
3
G
0
H
0
I
1
L
2
K
1
M
0
F
3
P
4
S
1
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 1 D: 2 C: 8 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 3 S: 4 T: 1 W: 2 Y: 2 V: 0
Chemical Descriptors
37
C168H255N51O52S9
4109.72
7.84
+2
2.55
-0.500
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons. {ECO:0000269|PubMed:2914898}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve.
Mu-agatoxin-Aa1b (Mu-AGTX-Aa1b) (Mu-agatoxin II) (Mu-Aga II) (Mu-agatoxin-2)
spider
Neurotoxin 07 (Beta/delta-agtx) family, 01 (aga-2) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 07 (Beta/delta-agtx) family, 01 (aga-2) subfamily
Mu-agatoxin-Aa1b (Mu-AGTX-Aa1b) (Mu-agatoxin II) (Mu-Aga II) (Mu-agatoxin-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2914898}.
spider