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Peptide record

TPDB30230

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB30230
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECRYLFGGCKTTADCCKHLGCKFRDKYCAWDFTFS
Physicochemical Analysis
C181H264N48O50S6
NQIMPV
C
4104.74
8.02
7
4
11
+2
1.68
-0.343
28.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
8855
215.73
12
Residue Composition
number
2
A
2
R
0
N
3
D
6
C
1
E
0
Q
3
G
1
H
0
I
2
L
4
K
0
M
4
F
0
P
1
S
3
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 3 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 4 M: 0 F: 4 P: 0 S: 1 T: 3 W: 1 Y: 2 V: 0
Chemical Descriptors
35
C181H264N48O50S6
4104.74
8.02
+2
1.68
-0.343
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels. Inhibits Kv2.1/KCNB1 channels, by shifting activation of the channel to more depolarized voltages. The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. May need to partition into the membrane in order to bind to the channel. Antibacterial activity is not observed.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels. Inhibits Kv2.1/KCNB1 channels, by shifting activation of the channel to more depolarized voltages.
Kappa-theraphotoxin-Gr1b (Kappa-TRTX-Gr1b) (Hanatoxin-2) (HaTx2)
spider
Neurotoxin 10 (Hwtx-1) family, 09 (HaTx) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 09 (HaTx) subfamily
Kappa-theraphotoxin-Gr1b (Kappa-TRTX-Gr1b) (Hanatoxin-2) (HaTx2)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider