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Peptide record

TPDB30228

Neurotoxin Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB30228
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ECRYFWGECNDEMVCCEHLVCKEKWPITYKICVWDRTF
Physicochemical Analysis
C213H309N53O58S7
AQS
C
4764.54
4.90
6
7
14
-2
6.94
-0.334
53.68
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
19855
416.72
11
Residue Composition
number
0
A
2
R
1
N
2
D
6
C
5
E
0
Q
1
G
1
H
2
I
1
L
3
K
1
M
2
F
1
P
0
S
2
T
3
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 2 C: 6 E: 5 Q: 0 G: 1 H: 1 I: 2 L: 1 K: 3 M: 1 F: 2 P: 1 S: 0 T: 2 W: 3 Y: 2 V: 3
Chemical Descriptors
38
C213H309N53O58S7
4764.54
4.90
-2
6.94
-0.334
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels. It specifically inhibits Kv2.1/KCNB1 channels. {ECO:0000269|PubMed:12065754}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels. It specifically inhibits Kv2.1/KCNB1 channels..
Kappa-theraphotoxin-Hm2a (Kappa-TRTX-Hm2a) (Heteroscodratoxin-2) (HmTx2)
spider
Neurotoxin 10 (Hwtx-1) family, 13 (Hntx-13) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12065754}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 13 (Hntx-13) subfamily
Kappa-theraphotoxin-Hm2a (Kappa-TRTX-Hm2a) (Heteroscodratoxin-2) (HmTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12065754}.
spider