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Peptide record

TPDB30210

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB30210
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECRWYLGGCKEDSECCEHLQCHSYWEWCLWDGSF
Physicochemical Analysis
C184H247N47O55S6
ANIMPTV
C
4189.63
4.26
4
7
10
-5
3.75
-0.688
34.41
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
25355
605.19
12
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
5
E
1
Q
3
G
2
H
0
I
3
L
1
K
0
M
1
F
0
P
3
S
0
T
4
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 5 Q: 1 G: 3 H: 2 I: 0 L: 3 K: 1 M: 0 F: 1 P: 0 S: 3 T: 0 W: 4 Y: 2 V: 0
Chemical Descriptors
34
C184H247N47O55S6
4189.63
4.26
-5
3.75
-0.688
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Selectively activates mammalian TRPV1, or capsaicin receptor, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is more potent than VaTx1 and VaTx2. Interacts with distinct regions of the channel than capsaicin, since it only acts on the extracellular face of the channel, and capsaicin binds to the cytosolic side. Also activates avian TRPV1, which is insensitive to capsaicin. In mice, elicits pain-related behaviors, such as licking and flinching of the affected limb. The paw of toxin-injected mice shows substantial edema. {ECO:0000269|PubMed:17093448}.

Target

TRP channel

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Psalmopoeus cambridgei (Trinidad chevron tarantula)
Neurotoxin Ion channel impairing toxin
Selectively activates mammalian TRPV1, or capsaicin receptor, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is more potent than VaTx1 and VaTx2.
Tau-theraphotoxin-Pc1c (Tau-TRTX-Pc1c) (Vanillotoxin-3) (VaTx3)
spider
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17093448}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 62 (Vatx) subfamily
Tau-theraphotoxin-Pc1c (Tau-TRTX-Pc1c) (Vanillotoxin-3) (VaTx3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17093448}.
spider