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Peptide record

TPDB30153

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB30153
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
ECLGFGKGCNPSNDQCCKSANLVCSRKHRWCKYEI
Physicochemical Analysis
C166H262N52O50S6
MT
C
3978.58
8.31
7
3
8
+3
7.63
-0.680
44.57
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
7365
185.12
14
Residue Composition
number
1
A
2
R
3
N
1
D
6
C
2
E
1
Q
3
G
1
H
1
I
2
L
4
K
0
M
1
F
1
P
3
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 3 D: 1 C: 6 E: 2 Q: 1 G: 3 H: 1 I: 1 L: 2 K: 4 M: 0 F: 1 P: 1 S: 3 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
35
C166H262N52O50S6
3978.58
8.31
+3
7.63
-0.680
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits selectively tetrodotoxin-sensitive voltage-gated sodium channels (Nav). Does not act by binding to receptor site 3 to slow the inactivation kinetics of sodium currents. {ECO:0000269|PubMed:12727268}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits selectively tetrodotoxin-sensitive voltage-gated sodium channels (Nav). Does not act by binding to receptor site 3 to slow the inactivation kinetics of sodium currents..
Mu-theraphotoxin-Hhn1a (Mu-TRTX-Hhn1a) (Hainantoxin-5) (Hainantoxin-V) (HnTX-V)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-Hhn1a (Mu-TRTX-Hhn1a) (Hainantoxin-5) (Hainantoxin-V) (HnTX-V)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider