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Peptide record

TPDB30136

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB30136
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
ECKTNKMSCSLHEECCRFRCCFHGKCQTSVFGCWVDP
Physicochemical Analysis
C179H273N53O53S9
AIY
C
4304.00
7.51
7
4
8
+1
8.13
-0.343
26.22
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
6000
139.41
15
Residue Composition
number
0
A
2
R
1
N
1
D
8
C
3
E
1
Q
2
G
2
H
0
I
1
L
3
K
1
M
3
F
1
P
3
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 8 E: 3 Q: 1 G: 2 H: 2 I: 0 L: 1 K: 3 M: 1 F: 3 P: 1 S: 3 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
37
C179H273N53O53S9
4304.00
7.51
+1
8.13
-0.343
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Causes hyperactivity, circular motion, convulsion, urination and death, when injected into 13- to 15-day-old mice. Causes gasping, backward swimming or swimming in a vertical direction and death, when intraperitoneally injected into goldfish.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin
Causes hyperactivity, circular motion, convulsion, urination and death, when injected into 13- to 15-day-old mice. Causes gasping, backward swimming or swimming in a vertical direction and death, when intraperitoneally injected into goldfish.
Conotoxin r11e
cone snail
Conotoxin I1 superfamily
Evidence at protein level
Bromination Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Bromination Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
Conotoxin I1 superfamily
Conotoxin r11e
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail