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Peptide record

TPDB30122

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB30122
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
EACYPPGTFCGIKPGLCCSELCLPAVCVG
Physicochemical Analysis
C127H200N30O37S6
RNDQHMW
C
2931.52
4.26
1
2
10
-1
1.44
0.828
80.69
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1865
63.62
9
Residue Composition
number
2
A
0
R
0
N
0
D
6
C
2
E
0
Q
4
G
0
H
1
I
3
L
1
K
0
M
1
F
4
P
1
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 6 E: 2 Q: 0 G: 4 H: 0 I: 1 L: 3 K: 1 M: 0 F: 1 P: 4 S: 1 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
29
C127H200N30O37S6
2931.52
4.26
-1
1.44
0.828
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ermineus (Agate cone) (Chelyconus ermineus)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process..
Delta-conotoxin-like EVIB (Delta-EVIB) (Delta-EVIA)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Amidation Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Amidation Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin-like EVIB (Delta-EVIB) (Delta-EVIA)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail