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Peptide record

TPDB30120

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB30120
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
EACYNAGTFCGIKPGLCCSAICLSFVCISFDF
Physicochemical Analysis
C150H224N34O43S6
RQHMW
C
3383.99
4.07
1
2
14
-1
-3.72
1.103
79.38
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1865
55.11
12
Residue Composition
number
3
A
0
R
1
N
1
D
6
C
1
E
0
Q
3
G
0
H
3
I
2
L
1
K
0
M
4
F
1
P
3
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 2 K: 1 M: 0 F: 4 P: 1 S: 3 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
32
C150H224N34O43S6
3383.99
4.07
-1
-3.72
1.103
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process..
Delta-conotoxin-like MVID (Delta-MVID)
cone snail
Conotoxin O1 superfamily
Evidence at transcript level
Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin O1 superfamily
Delta-conotoxin-like MVID (Delta-MVID)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail