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Peptide record

TPDB30113

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB30113
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
EACAGAYKSCDKVKCCHDRRCRCNIAMDNCVCKLFYCELFGTCDRLKP
Physicochemical Analysis
C227H365N69O67S11
QW
C
5485.48
7.95
10
6
15
+3
10.39
-0.233
52.92
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
3605
65.72
16
Residue Composition
number
4
A
4
R
2
N
4
D
10
C
2
E
0
Q
2
G
1
H
1
I
3
L
5
K
1
M
2
F
1
P
1
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 4 C: 10 E: 2 Q: 0 G: 2 H: 1 I: 1 L: 3 K: 5 M: 1 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
48
C227H365N69O67S11
5485.48
7.95
+3
10.39
-0.233
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: The toxin blocks voltage-gated calcium channels in rat cerebellar granule cells (IC(50)=200 nM). {ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
The toxin blocks voltage-gated calcium channels in rat cerebellar granule cells (IC(50)=200 nM)..
Omega-agatoxin-Aa5a (Omega-AGTX-Aa5a) (Peptide J2)
spider
Neurotoxin 02 (plectoxin) family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family
Omega-agatoxin-Aa5a (Omega-AGTX-Aa5a) (Peptide J2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider