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Peptide record

TPDB30044

Neurotoxin Toxicity standard
69 amino acids
Basic Information
3D PDB MODEL
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TPDB30044
Neurotoxin Toxicity
Toxicity and safety peptides
Peptipedia
standard
No
A 69-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
DWECLPLHSSCDNDCVCCKNHHCHCPYSNVSKLEKWLPEWAKIPDALKRCSCQRNDKDGKINTCDKYKN
Physicochemical Analysis
C342H528N102O105S10
MF
C
8069.17
7.43
15
10
16
+1
21.29
-0.988
50.87
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
20105
249.16
25
Residue Composition
number
2
A
2
R
6
N
7
D
10
C
3
E
1
Q
1
G
4
H
2
I
5
L
9
K
0
M
0
F
4
P
5
S
1
T
3
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 6 D: 7 C: 10 E: 3 Q: 1 G: 1 H: 4 I: 2 L: 5 K: 9 M: 0 F: 0 P: 4 S: 5 T: 1 W: 3 Y: 2 V: 2
Chemical Descriptors
69
C342H528N102O105S10
8069.17
7.43
+1
21.29
-0.988
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2). Is both paralytic and lethal when injected into lepidopteran larvae. Is not toxic to mice. {ECO:0000269|PubMed:18606178}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Oxyopes lineatus (Lynx spider)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2). Is both paralytic and lethal when injected into lepidopteran larvae.
Omega-oxotoxin-Ol1a (Omega-OXTX-Ol1a) (Oxytoxin-1) (OxyTx1)
spider
Spiderine family, Spiderine subfamily
Evidence at protein level
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18606178}.
Additional Detail Fields 7 fields
Amidation Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Spiderine family, Spiderine subfamily
Omega-oxotoxin-Ol1a (Omega-OXTX-Ol1a) (Oxytoxin-1) (OxyTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:18606178}.
spider