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Peptide record

TPDB30033

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB30033
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCESVAGRCIHNGCWCERSAPHGNCCNTSGCTARWWCPGTKWD
Physicochemical Analysis
C200H295N65O62S8
QLMFY
C
4858.42
6.85
6
4
10
-0
4.86
-0.530
28.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
22500
463.11
17
Residue Composition
number
3
A
3
R
3
N
2
D
8
C
2
E
0
Q
5
G
2
H
1
I
0
L
1
K
0
M
0
F
2
P
3
S
3
T
4
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 3 N: 3 D: 2 C: 8 E: 2 Q: 0 G: 5 H: 2 I: 1 L: 0 K: 1 M: 0 F: 0 P: 2 S: 3 T: 3 W: 4 Y: 0 V: 2
Chemical Descriptors
44
C200H295N65O62S8
4858.42
6.85
-0
4.86
-0.530
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.2f (Conotoxin CalTx 12.1.3D)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.2f (Conotoxin CalTx 12.1.3D)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail