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Peptide record

TPDB30030

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB30030
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCDSLVGGRCIHNGCYCERDAPNGNCCNTDGCTARWWCPGTKWD
Physicochemical Analysis
C202H300N64O67S8
QMF
C
4953.47
4.62
5
6
10
-2
6.26
-0.618
34.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
18490
373.27
17
Residue Composition
number
2
A
3
R
4
N
5
D
8
C
1
E
0
Q
6
G
1
H
1
I
1
L
1
K
0
M
0
F
2
P
1
S
3
T
3
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 4 D: 5 C: 8 E: 1 Q: 0 G: 6 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 3 W: 3 Y: 1 V: 2
Chemical Descriptors
45
C202H300N64O67S8
4953.47
4.62
-2
6.26
-0.618
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.2c (Conotoxin CalTx 12.1.2D)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.2c (Conotoxin CalTx 12.1.2D)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail