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Peptide record

TPDB30021

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB30021
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCDSLVGGHCIHNGCWCDQDAPHGNCCDTGGCVWWWCPGTKWD
Physicochemical Analysis
C205H283N59O63S8
REMFY
C
4838.34
4.15
4
6
11
-5
2.05
-0.341
39.77
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
28000
578.71
14
Residue Composition
number
1
A
0
R
2
N
6
D
8
C
0
E
1
Q
7
G
3
H
1
I
1
L
1
K
0
M
0
F
2
P
1
S
2
T
5
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 6 C: 8 E: 0 Q: 1 G: 7 H: 3 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 2 W: 5 Y: 0 V: 3
Chemical Descriptors
44
C205H283N59O63S8
4838.34
4.15
-5
2.05
-0.341
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.1e (Conotoxin CalTx 12.1.1G)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.1e (Conotoxin CalTx 12.1.1G)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail