Back to search

Peptide record

TPDB30018

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB30018
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCDSLVEGRCIHNGCWCDEEAPHGNCCDTAGCTAWWWCPGTKWD
Physicochemical Analysis
C212H298N60O68S8
QMFY
C
5031.54
4.00
4
8
12
-6
5.86
-0.451
36.89
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
28000
556.49
14
Residue Composition
number
3
A
1
R
2
N
5
D
8
C
3
E
0
Q
5
G
2
H
1
I
1
L
1
K
0
M
0
F
2
P
1
S
3
T
5
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 5 C: 8 E: 3 Q: 0 G: 5 H: 2 I: 1 L: 1 K: 1 M: 0 F: 0 P: 2 S: 1 T: 3 W: 5 Y: 0 V: 2
Chemical Descriptors
45
C212H298N60O68S8
5031.54
4.00
-6
5.86
-0.451
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.1d (Conotoxin CalTx 12.1.1E)
cone snail
Evidence at transcript level
Bromination Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.1d (Conotoxin CalTx 12.1.1E)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail