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Peptide record

TPDB30013

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB30013
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCDSLVDGRCIHNGCFCERDAPNGNCCDTDGCTARWWCPGTKWD
Physicochemical Analysis
C204H301N63O69S8
QMY
C
4996.49
4.13
5
8
10
-4
8.10
-0.596
34.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
17000
340.24
15
Residue Composition
number
2
A
3
R
3
N
7
D
8
C
1
E
0
Q
5
G
1
H
1
I
1
L
1
K
0
M
1
F
2
P
1
S
3
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 3 D: 7 C: 8 E: 1 Q: 0 G: 5 H: 1 I: 1 L: 1 K: 1 M: 0 F: 1 P: 2 S: 1 T: 3 W: 3 Y: 0 V: 2
Chemical Descriptors
45
C204H301N63O69S8
4996.49
4.13
-4
8.10
-0.596
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.2a (Conotoxin CalTx 12.1.2B)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.2a (Conotoxin CalTx 12.1.2B)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail