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Peptide record

TPDB30008

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB30008
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DVCDSLVDGRCIHNGCFCEESKPNGNCCDSGGCVWWWCPGTKWD
Physicochemical Analysis
C205H294N58O66S8
AQMY
C
4883.42
4.10
4
7
10
-4
5.58
-0.434
37.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
22500
460.74
15
Residue Composition
number
0
A
1
R
3
N
5
D
8
C
2
E
0
Q
6
G
1
H
1
I
1
L
2
K
0
M
1
F
2
P
3
S
1
T
4
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 3 D: 5 C: 8 E: 2 Q: 0 G: 6 H: 1 I: 1 L: 1 K: 2 M: 0 F: 1 P: 2 S: 3 T: 1 W: 4 Y: 0 V: 3
Chemical Descriptors
44
C205H294N58O66S8
4883.42
4.10
-4
5.58
-0.434
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation (By similarity)..
Mu-conotoxin-like Cal 12.1.3b (Conotoxin CalTx 12.1.4D)
cone snail
Evidence at transcript level
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Bromination Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Mu-conotoxin-like Cal 12.1.3b (Conotoxin CalTx 12.1.4D)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail