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Peptide record

TPDB29993

Neurotoxin Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB29993
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 41-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DQPAERMQDDISSEHHPFFDPVKRCCKYGWTCVLGCSPCGC
Physicochemical Analysis
C197H294N56O61S7
N
C
4647.26
5.27
6
6
10
-2
10.38
-0.563
35.61
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7365
158.48
13
Residue Composition
number
1
A
2
R
0
N
4
D
6
C
2
E
2
Q
3
G
2
H
1
I
1
L
2
K
1
M
2
F
4
P
3
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 4 C: 6 E: 2 Q: 2 G: 3 H: 2 I: 1 L: 1 K: 2 M: 1 F: 2 P: 4 S: 3 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
41
C197H294N56O61S7
4647.26
5.27
-2
10.38
-0.563
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes (By similarity). Induces paralysis in mollusks (C.retripictus) (PubMed:28831846). {ECO:0000250, ECO:0000269|PubMed:28831846}.

Target

voltage-gated sodium channel (Nav) proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus pennaceus (Feathered cone) (Conus episcopus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Mu-conotoxins block voltage-gated sodium channels (Nav). Blocks reversibly sodium channels in molluskan neurons, but has no effect on sodium currents in bovine chromaffin cells or in rat brain synaptosomes (By similarity).
Mu-conotoxin pn4c (Mu-conotoxin-like PnMMSK-D013)
cone snail
Conotoxin M superfamily
Evidence at protein level
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11158371}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin M superfamily
Mu-conotoxin pn4c (Mu-conotoxin-like PnMMSK-D013)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:11158371}.
cone snail