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Peptide record

TPDB29987

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB29987
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DSDCKDKLPACGEYRGSFCKLEKVKSNCEKTCGVKC
Physicochemical Analysis
C164H271N47O55S6
QHIMW
K
3973.60
8.01
8
6
7
+2
14.26
-0.775
40.56
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1865
46.93
12
Residue Composition
number
1
A
1
R
1
N
3
D
6
C
3
E
0
Q
3
G
0
H
0
I
2
L
7
K
0
M
1
F
1
P
3
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 3 C: 6 E: 3 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 7 M: 0 F: 1 P: 1 S: 3 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
36
C164H271N47O55S6
3973.60
8.01
+2
14.26
-0.775
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Has hemolytic activity (Ref.1). Inhibits voltage-gated potassium channels (Kv1/KCNA) (By similarity). {ECO:0000250|UniProtKB:P29186, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Metridium senile (Brown sea anemone) (Frilled sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Has hemolytic activity (Ref.1). Inhibits voltage-gated potassium channels (Kv1/KCNA) (By similarity)..
U-metritoxin-Msn1a (U-MTTX-Msn1a) (Metridin)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
Cytolysis Direct protein sequencing Disulfide bond Hemolysis Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Cytolysis Direct protein sequencing Disulfide bond Hemolysis Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
U-metritoxin-Msn1a (U-MTTX-Msn1a) (Metridin)
sea anemone