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Peptide record

TPDB29983

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB29983
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DRDSCVDKSRCSKYGYYQECQDCCKKAGHNGGTCMFFKCKCA
Physicochemical Analysis
C195H301N59O63S9
ILPW
C
4768.43
8.09
9
5
9
+3
10.11
-0.879
11.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
4970
104.23
18
Residue Composition
number
2
A
2
R
1
N
4
D
8
C
1
E
2
Q
4
G
1
H
0
I
0
L
6
K
1
M
2
F
0
P
3
S
1
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 4 C: 8 E: 1 Q: 2 G: 4 H: 1 I: 0 L: 0 K: 6 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 1
Chemical Descriptors
42
C195H301N59O63S9
4768.43
8.09
+3
10.11
-0.879
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels. Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels. {ECO:0000269|PubMed:18338253}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels. Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels..
Potassium channel toxin gamma-KTx 1.7 (CeErgTx4) (CeErg4)
scorpion
Ergtoxin family, Gamma-KTx 1 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Blocks Kv11/ERG potassium channels. {ECO:0000250|UniProtKB:Q86QT3}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limpidus (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Kv11/ERG potassium channels..
Potassium channel toxin gamma-KTx 1.5 (CllErgTx1) (CllErg1) (Ergtoxin-like protein)
scorpion
Ergtoxin family, Gamma-KTx 1 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 1 subfamily
Potassium channel toxin gamma-KTx 1.7 (CeErgTx4) (CeErg4) Potassium channel toxin gamma-KTx 1.5 (CllErgTx1) (CllErg1) (Ergtoxin-like protein)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion