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Peptide record

TPDB29965

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB29965
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DRDSCVDKSKCSKYGYYGQCDECCKKAGDRAGNCVYFKCKCNP
Physicochemical Analysis
C199H309N59O66S8
HILMTW
C
4840.48
8.09
9
6
9
+3
12.01
-1.019
18.14
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
6460
133.46
18
Residue Composition
number
2
A
2
R
2
N
5
D
8
C
1
E
1
Q
4
G
0
H
0
I
0
L
7
K
0
M
1
F
1
P
3
S
0
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 5 C: 8 E: 1 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 7 M: 0 F: 1 P: 1 S: 3 T: 0 W: 0 Y: 4 V: 2
Chemical Descriptors
43
C199H309N59O66S8
4840.48
8.09
+3
12.01
-1.019
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks Kv11/ERG potassium channels. {ECO:0000250|UniProtKB:P59940}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limpidus (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly blocks Kv11/ERG potassium channels..
Potassium channel toxin gamma-KTx 4.1 (CllErgTx2) (CllErg2) (ErgTx2) (Ergtoxin-like protein)
scorpion
Ergtoxin family, Gamma-KTx 4 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 4 subfamily
Potassium channel toxin gamma-KTx 4.1 (CllErgTx2) (CllErg2) (ErgTx2) (Ergtoxin-like protein)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion