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Peptide record

TPDB29958

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB29958
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DRDSCIDKSRCSKYGYYQECQDCCKKAGHNRGTCMFFKCKCA
Physicochemical Analysis
C200H312N62O63S9
LPWV
C
4881.60
8.30
10
5
9
+4
10.53
-0.969
14.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
4970
101.81
18
Residue Composition
number
2
A
3
R
1
N
4
D
8
C
1
E
2
Q
3
G
1
H
1
I
0
L
6
K
1
M
2
F
0
P
3
S
1
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 4 C: 8 E: 1 Q: 2 G: 3 H: 1 I: 1 L: 0 K: 6 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 0
Chemical Descriptors
42
C200H312N62O63S9
4881.60
8.30
+4
10.53
-0.969
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks human voltage-gated potassium channel Kv11.1/KCNH2/ERG1 (IC(50)=16.9 nM). {ECO:0000269|PubMed:26921461}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks human voltage-gated potassium channel Kv11.1/KCNH2/ERG1 (IC(50)=16.9 nM)..
Potassium channel gamma toxin gamma-KTx 1.9 (Toxin II.10.9)
scorpion
Ergtoxin family, Gamma-KTx 1 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 1 subfamily
Potassium channel gamma toxin gamma-KTx 1.9 (Toxin II.10.9)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26921461}.
scorpion