Back to search

Peptide record

TPDB29957

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB29957
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DRDSCIDKSRCSKYGYYQECQDCCKKAGHNGGTCMFFKCKCA
Physicochemical Analysis
C196H303N59O63S9
LPWV
C
4782.46
8.09
9
5
9
+3
9.73
-0.871
14.05
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
4970
103.92
18
Residue Composition
number
2
A
2
R
1
N
4
D
8
C
1
E
2
Q
4
G
1
H
1
I
0
L
6
K
1
M
2
F
0
P
3
S
1
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 4 C: 8 E: 1 Q: 2 G: 4 H: 1 I: 1 L: 0 K: 6 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 3 V: 0
Chemical Descriptors
42
C196H303N59O63S9
4782.46
8.09
+3
9.73
-0.871
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels (PubMed:18338253). Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels (PubMed:18338253). Also weakly inhibits Kir2.1/KCNJ2 and Kv1.2/KCNA2 potassium channels (PubMed:29483648). {ECO:0000269|PubMed:18338253, ECO:0000269|PubMed:29483648}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides elegans (Bark scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks in a reversible manner human and rat Kv11.1/KCNH2/ERG1 potassium channels (PubMed:18338253). Also completely and irreversibly blocks rat Kv11.2/KCNH6/ERG2 and human Kv11.3/KCNH7/ERG3 channels (PubMed:18338253).
Potassium channel toxin gamma-KTx 1.8 (CeErgTx5) (CeErg5)
scorpion
Ergtoxin family, Gamma-KTx 1 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18338253}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Ergtoxin family, Gamma-KTx 1 subfamily
Potassium channel toxin gamma-KTx 1.8 (CeErgTx5) (CeErg5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:18338253}.
scorpion