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Peptide record

TPDB29922

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB29922
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DPCCGYRMCVPC
Physicochemical Analysis
C53H83N15O16S5
ANEQHILKFSTW
C
1346.63
5.80
1
1
3
-0
0.89
0.267
24.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1740
129.21
5
Residue Composition
number
0
A
1
R
0
N
1
D
4
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
12
C53H83N15O16S5
1346.63
5.80
-0
0.89
0.267
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2). {ECO:0000250|UniProtKB:P58808}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin
Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2)..
Chi-conotoxin-like 1 (Tx10b)
cone snail
Conotoxin T superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Oxidation Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:22709442}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Oxidation Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin T superfamily
Chi-conotoxin-like 1 (Tx10b)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747, ECO:0000305|PubMed:22709442}.
cone snail