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Peptide record

TPDB29906

Antiviral Neurotoxin Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB29906
Antiviral Neurotoxin Toxicity
Anti-infective peptides Toxicity and safety peptides
AVPpred-BWR NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antiviral, Neurotoxin, and Toxicity) peptide sequence curated from AVPpred-BWR, NTxPred2, Peptipedia, and other sources, with an available 3D structural model.
Sequence
DNWWPKPPHQGPRPPRPRPKP
Physicochemical Analysis
C118H174N38O26
ACEILMFSTYV
P
2540.92
12.13
6
1
2
+4
7.96
-2.457
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
11000
432.91
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
1
G
1
H
0
I
0
L
2
K
0
M
0
F
9
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 0 K: 2 M: 0 F: 0 P: 9 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
21
C118H174N38O26
2540.92
12.13
+4
7.96
-2.457
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: In vitro, reversibly blocks human muscle-type nicotinic acetylcholine receptors (nAChR) alpha-1-beta-1-epsilon-delta/CHRNA1-CHRNB1-CHRNE-CHRND (EC(50)=0.44 uM) and alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (EC(50)=1.56 uM). Binds to nAChR from T.californica (IC(50)=0.03-0.18 uM), human neuronal nAChR alpha-7/CHRNA7 (IC(50)=22 uM) and acetylcholine-binding proteins (AChBP) from L.stagnalis (IC(50)=63 uM) and A.californica (IC(50)=230 uM). {ECO:0000269|PubMed:22613724}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Azemiops feae (Fea's viper)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
In vitro, reversibly blocks human muscle-type nicotinic acetylcholine receptors (nAChR) alpha-1-beta-1-epsilon-delta/CHRNA1-CHRNB1-CHRNE-CHRND (EC(50)=0.44 uM) and alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (EC(50)=1.56 uM). Binds to nAChR from T.californica (IC(50)=0.03-0.18 uM), human neuronal nAChR alpha-7/CHRNA7 (IC(50)=22 uM) and acetylcholine-binding proteins (AChBP) from L.stagnalis (IC(50)=63 uM) and A.californica (IC(50)=230 uM)..
Azemiopsin
snake
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 6 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Azemiopsin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
snake