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Peptide record

TPDB29891

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB29891
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DLIDVKCISSQECWIACKKVTGRFEGKCQNRQCRCY
Physicochemical Analysis
C177H288N54O53S6
HMP
C
4212.92
8.31
7
4
10
+3
8.59
-0.475
62.22
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7365
174.82
14
Residue Composition
number
1
A
3
R
1
N
2
D
6
C
2
E
3
Q
2
G
0
H
3
I
1
L
4
K
0
M
1
F
0
P
2
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 2 C: 6 E: 2 Q: 3 G: 2 H: 0 I: 3 L: 1 K: 4 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
36
C177H288N54O53S6
4212.92
8.31
+3
8.59
-0.475
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks calcium-activated potassium channels. {ECO:0000250}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks calcium-activated potassium channels..
Potassium channel toxin alpha-KTx 16.1 (Alpha-KTx 1.8) (Tamulotoxin) (TmTX)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Potassium channel toxin alpha-KTx 16.1 (Alpha-KTx 1.8) (Tamulotoxin) (TmTX)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion