TPDB

3D PDB MODEL

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TPDB ID TPDB29874

Activity

Neurotoxin Toxicity

Activity_category_statistics

Toxicity and safety peptides

Database_Source

NTxPred2 Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.

Sequence

DLFQFGKMIECANKGSRPSLDYMNYGCYCGK

FASTA

>TPDB29874|Neurotoxin;Toxicity|length=31
DLFQFGKMIECANKGSRPSLDYMNYGCYCGK

Formula C154H232N40O46S5

Absent Amino Acids HTWV

Common Amino Acids G

Mass 3540.08

PI 7.99

Basic Residues 4

Acidic Residues 3

Hydrophobic Residues 11

Net Charge +1

Boman Index 2.57

Hydrophobicity -0.487

Aliphatic Index 40.97

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 4595

Absorbance 280nm 129.80

Polar Residues 11

number

1

A

1

R

2

N

2

D

3

C

1

E

1

Q

4

G

0

H

1

I

2

L

3

K

2

M

2

F

1

P

2

S

0

T

0

W

3

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 2 D: 2 C: 3 E: 1 Q: 1 G: 4 H: 0 I: 1 L: 2 K: 3 M: 2 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 3 V: 0

Length

31

Formula

C154H232N40O46S5

Mass

3540.08

PI

7.99

Net Charge

+1

Boman Index

2.57

Hydrophobicity

-0.487

Evidence 1 Activity

Activity

Detail Source Activity Neurotoxin

Function Text

FUNCTION: Heterotrimer: Snake venom phospholipase A2 (PLA2) that has presynaptic neurotoxicity. Inhibits nerve-evoked twitch contractions but not responses to cholinergic agonists acetylcholine and carbachol and to depolarizing agonist KCl. Causes a fade in tetanic contractions. Displays a triphasic mode of action with depression, enhancement and blockade of neurotransmission. Does not display myotoxic activity such as changes in baseline muscle tension or inhibition of directly stimulated muscle twitches. All subunits are necessary for maximum toxicity. {ECO:0000269|PubMed:20361942}. FUNCTION: Monomer: The beta chain has no enzymatic activity and is not toxic by itself. {ECO:0000269|PubMed:20361942}.

Target

Target or Channel proton-gated sodium channel / ASIC

Source & Reference

Database Source NA

Source UniProtKB/Swiss-Prot Tox-Prot

Other

Organism Source Acanthophis antarcticus (Common death adder)

Neurotoxin Type Neurotoxin Presynaptic neurotoxin

Mechanism

Heterotrimer: Snake venom phospholipase A2 (PLA2) that has presynaptic neurotoxicity. Inhibits nerve-evoked twitch contractions but not responses to cholinergic agonists acetylcholine and carbachol and to depolarizing agonist KCl.

Protein Name Phospholipase A2 homolog P-elapitoxin-Aa1a beta chain (P-EPTX-Aa1a beta chain) (svPLA2 homolog)

Venom Taxon Group snake

Protein Family Phospholipase A2 family, Group I subfamily

Protein Existence Evidence at protein level

Keywords Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin

Tissue Specificity TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20361942}.

Keywords

Direct protein sequencing Disulfide bond Neurotoxin Presynaptic neurotoxin Secreted Toxin

Neurotoxin_Type

Neurotoxin Presynaptic neurotoxin

Protein_Existence

Evidence at protein level

Protein_Family

Phospholipase A2 family, Group I subfamily

Protein_Name

Phospholipase A2 homolog P-elapitoxin-Aa1a beta chain (P-EPTX-Aa1a beta chain) (svPLA2 homolog)

Tissue_Specificity

TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20361942}.

Venom_Taxon_Group

snake