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Peptide record

TPDB29794

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB29794
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DGCPPHPVPGMHPCMCTNTC
Physicochemical Analysis
C84H129N25O26S6
AREQILKFSWY
P
2097.46
5.99
2
1
3
-1
4.77
-0.280
14.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
250
11.92
7
Residue Composition
number
0
A
0
R
1
N
1
D
4
C
0
E
0
Q
2
G
2
H
0
I
0
L
0
K
2
M
0
F
5
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 1 C: 4 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 0 K: 0 M: 2 F: 0 P: 5 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C84H129N25O26S6
2097.46
5.99
-1
4.77
-0.280
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250|UniProtKB:C6ZJQ2}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tessulatus (Tessellate cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like ts14a
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20691232}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like ts14a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20691232}.
cone snail