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Peptide record

TPDB29777

Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB29777
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DEPEYAEAIREYQLKYGKI
Physicochemical Analysis
C105H159N25O34
NCHMFSTWV
E
2315.56
4.36
3
5
8
-2
8.80
-1.200
72.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
4470
193.04
4
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
4
E
1
Q
1
G
0
H
2
I
1
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 4 Q: 1 G: 1 H: 0 I: 2 L: 1 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 3 V: 0
Chemical Descriptors
19
C105H159N25O34
2315.56
4.36
-2
8.80
-1.200
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit and a smaller potency for the NR2D/GRIN2D subunits. It induces sleep in 10-day-old mice when injected intracranially, and hyperactivity in 24-day-old mice. {ECO:0000269|PubMed:17962189}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus parius (Cone snail)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit and a smaller potency for the NR2D/GRIN2D subunits.
Conantokin-Pr2 (Con-Pr2)
cone snail
Conotoxin B superfamily
Evidence at protein level
Calcium Direct protein sequencing Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conotoxin B superfamily
Conantokin-Pr2 (Con-Pr2)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
cone snail