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Peptide record

TPDB29769

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB29769
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DEEPKETCSDDMCVIYCKGEEFSTGACDGPQKCKCS
Physicochemical Analysis
C158H247N41O62S7
RNHLW
C
3937.36
3.98
4
9
6
-5
17.01
-0.831
21.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1865
47.37
13
Residue Composition
number
1
A
0
R
0
N
4
D
6
C
5
E
1
Q
3
G
0
H
1
I
0
L
4
K
1
M
1
F
2
P
3
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 4 C: 6 E: 5 Q: 1 G: 3 H: 0 I: 1 L: 0 K: 4 M: 1 F: 1 P: 2 S: 3 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
36
C158H247N41O62S7
3937.36
3.98
-5
17.01
-0.831
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity. {ECO:0000269|PubMed:14561751}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Parabuthus granulatus (Granulated thick-tailed scorpion) (Androctonus granulatus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity..
Potassium channel toxin alpha-KTx 11.3 (Parabutoxin-10) (PBTx10)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 11 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14561751}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 11 subfamily
Potassium channel toxin alpha-KTx 11.3 (Parabutoxin-10) (PBTx10)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:14561751}.
scorpion