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Peptide record

TPDB29761

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB29761
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DECFSPGTFCGTKPGLCCSARCFSFFCISLEF
Physicochemical Analysis
C155H224N36O45S6
NQHMWYV
CF
3504.06
4.44
2
3
10
-1
-1.02
0.556
39.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
375
10.70
12
Residue Composition
number
1
A
1
R
0
N
1
D
6
C
2
E
0
Q
3
G
0
H
1
I
2
L
1
K
0
M
6
F
2
P
4
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 6 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 1 M: 0 F: 6 P: 2 S: 4 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C155H224N36O45S6
3504.06
4.44
-1
-1.02
0.556
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. This toxin acts on Nav1.4/SCN4A and Nav1.6/SCN8A (EC(50)=2.3 uM). {ECO:0000269|PubMed:25352593}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus consors (Singed cone)
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. This toxin acts on Nav1.4/SCN4A and Nav1.6/SCN8A (EC(50)=2.3 uM)..
Delta-conotoxin-like CnVIB (Delta-CnVIB)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19457347}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin-like CnVIB (Delta-CnVIB)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19457347}.
cone snail