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Peptide record

TPDB29733

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB29733
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
DDDCGWIMDDCTSDSDCCPNWVCSKTGFVKNICKYEM
Physicochemical Analysis
C175H260N44O62S8
ARQHL
D
4228.73
3.69
3
8
10
-5
7.43
-0.459
36.76
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
12865
304.23
14
Residue Composition
number
0
A
0
R
2
N
7
D
6
C
1
E
0
Q
2
G
0
H
2
I
0
L
3
K
2
M
1
F
1
P
3
S
2
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 7 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 3 M: 2 F: 1 P: 1 S: 3 T: 2 W: 2 Y: 1 V: 2
Chemical Descriptors
37
C175H260N44O62S8
4228.73
3.69
-5
7.43
-0.459
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks calcium channels (Cav). {ECO:0000269|Ref.1}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Blocks calcium channels (Cav)..
Omega-sparatoxin-Hv1a (Omega-SPRTX-Hv1a) (Toxin AU5A)
spider
Neurotoxin 10 (Hwtx-1) family, 01 (AU5A) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 01 (AU5A) subfamily
Omega-sparatoxin-Hv1a (Omega-SPRTX-Hv1a) (Toxin AU5A)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider