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Peptide record

TPDB29704

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB29704
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCLGMFSSCDPKNDKCCPNRVCRSRDQWCKYKLW
Physicochemical Analysis
C176H271N53O53S7
AEHIT
C
4201.83
8.02
7
5
8
+2
6.77
-0.991
30.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
12865
306.18
13
Residue Composition
number
0
A
3
R
2
N
5
D
6
C
0
E
1
Q
1
G
0
H
0
I
2
L
4
K
1
M
1
F
2
P
3
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 5 C: 6 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 4 M: 1 F: 1 P: 2 S: 3 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
35
C176H271N53O53S7
4201.83
8.02
+2
6.77
-0.991
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Low-affinity blocker of Kv4.2/KCND2 voltage-gated potassium channels. Is presumed to shift the voltage-dependence of channel activation to more depolarized potentials and to bind to the S3-S4 linker region of the voltage sensor domain. {ECO:0000269|PubMed:15150824, ECO:0000269|PubMed:15208026}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Theraphosa blondi (Goliath birdeating spider)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Low-affinity blocker of Kv4.2/KCND2 voltage-gated potassium channels. Is presumed to shift the voltage-dependence of channel activation to more depolarized potentials and to bind to the S3-S4 linker region of the voltage sensor domain..
Kappa-theraphotoxin-Tb1b (Kappa-TRTX-Tb1b) (Theraphotoxin-2) (TlTx2)
spider
Neurotoxin 10 (Hwtx-1) family, 58 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 58 subfamily
Kappa-theraphotoxin-Tb1b (Kappa-TRTX-Tb1b) (Theraphotoxin-2) (TlTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider