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Peptide record

TPDB29703

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB29703
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCLGMFSSCDPDNDKCCEGRKCNRKDKWCKYVL
Physicochemical Analysis
C163H256N48O54S7
AQHIT
DC
3976.54
6.17
7
7
7
-0
10.90
-1.021
31.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7365
185.21
11
Residue Composition
number
0
A
2
R
2
N
6
D
6
C
1
E
0
Q
2
G
0
H
0
I
2
L
5
K
1
M
1
F
1
P
2
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 6 C: 6 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 5 M: 1 F: 1 P: 1 S: 2 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
34
C163H256N48O54S7
3976.54
6.17
-0
10.90
-1.021
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Spider venom neurotoxin that blocks voltage-gated sodium channels Nav1.3/SCN3A and Nav1.8/SCN10A in human (IC(50)=2 uM and IC(50)=4 uM, respectively) and rat (IC(50)=2 uM and IC(50)=2.5 uM, respectively). {ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pterinochilus murinus (Mombasa golden starburst baboon spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Spider venom neurotoxin that blocks voltage-gated sodium channels Nav1.3/SCN3A and Nav1.8/SCN10A in human (IC(50)=2 uM and IC(50)=4 uM, respectively) and rat (IC(50)=2 uM and IC(50)=2.5 uM, respectively)..
Beta-theraphotoxin-Pmu1a (Beta-TRTX-Pmu1a) (Beta-theraphotoxin-Pm1a) (Beta-TRTX-Pm1a) (Pterinotoxin-1)
spider
Neurotoxin 10 (Hwtx-1) family, 34 (Jztx-26) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 34 (Jztx-26) subfamily
Beta-theraphotoxin-Pmu1a (Beta-TRTX-Pmu1a) (Beta-theraphotoxin-Pm1a) (Beta-TRTX-Pm1a) (Pterinotoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider