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Peptide record

TPDB29698

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB29698
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCGTLFSGCDTSKDCCEGYVCHLWCKYK
Physicochemical Analysis
C138H203N35O46S6
ARNQIMP
C
3280.70
4.54
4
5
7
-2
4.09
-0.362
36.90
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8855
269.91
12
Residue Composition
number
0
A
0
R
0
N
4
D
6
C
1
E
0
Q
3
G
1
H
0
I
2
L
3
K
0
M
1
F
0
P
2
S
2
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 4 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 2 T: 2 W: 1 Y: 2 V: 1
Chemical Descriptors
29
C138H203N35O46S6
3280.70
4.54
-2
4.09
-0.362
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels of the Kv4/KCND family (By similarity). Blocks calcium channels (Cav). {ECO:0000250, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels of the Kv4/KCND family (By similarity). Blocks calcium channels (Cav)..
Kappa-sparatoxin-Hv1e (Kappa-SPRTX-Hv1e) (Toxin KJ1)
spider
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Kappa-sparatoxin-Hv1e (Kappa-SPRTX-Hv1e) (Toxin KJ1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider