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Peptide record

TPDB29696

Neurotoxin Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB29696
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCGGLFSGCDSNADCCEGYVCRLWCKYKL
Physicochemical Analysis
C139H207N37O46S6
QHIMPT
C
3324.75
4.12
3
5
9
-2
2.37
-0.160
52.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8855
266.34
11
Residue Composition
number
1
A
1
R
1
N
4
D
6
C
1
E
0
Q
4
G
0
H
0
I
3
L
2
K
0
M
1
F
0
P
2
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 4 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 0 L: 3 K: 2 M: 0 F: 1 P: 0 S: 2 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
30
C139H207N37O46S6
3324.75
4.12
-2
2.37
-0.160
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels of the Kv4/KCND family (By similarity). Blocks calcium channels (Cav). {ECO:0000250, ECO:0000269|Ref.1}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels of the Kv4/KCND family (By similarity). Blocks calcium channels (Cav)..
Kappa-sparatoxin-Hv1d (Kappa-SPRTX-Hv1d) (Toxin AU2)
spider
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily
Kappa-sparatoxin-Hv1d (Kappa-SPRTX-Hv1d) (Toxin AU2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider