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Peptide record

TPDB29673

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB29673
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCTRMFGACRRDSDCCPHLGCKPTSKYCAWDGTI
Physicochemical Analysis
C156H242N48O49S7
NEQV
C
3798.35
7.64
6
4
8
+1
5.10
-0.506
28.82
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
7365
193.90
12
Residue Composition
number
2
A
3
R
0
N
4
D
6
C
0
E
0
Q
3
G
1
H
1
I
1
L
2
K
1
M
1
F
2
P
2
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 4 C: 6 E: 0 Q: 0 G: 3 H: 1 I: 1 L: 1 K: 2 M: 1 F: 1 P: 2 S: 2 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
34
C156H242N48O49S7
3798.35
7.64
+1
5.10
-0.506
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC(50) is 12.7 nM), Kv2.1/Kv9.3 (IC(50) is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC(50) is 21.4 nM), and transient Kv4.2/KCND2 (IC(50) is 1.2 nM) channels. {ECO:0000269|PubMed:12065754}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Stromatopelma calceatum (Featherleg baboon tarantula) (Scodra calceata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC(50) is 12.7 nM), Kv2.1/Kv9.3 (IC(50) is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC(50) is 21.4 nM), and transient Kv4.2/KCND2 (IC(50) is 1.2 nM) channels..
Kappa-theraphotoxin-Sc1a (Kappa-TRTX-Sc1a) (Stromatoxin-1) (ScTx1)
spider
Neurotoxin 10 (Hwtx-1) family, 57 (ScTx1) subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 57 (ScTx1) subfamily
Kappa-theraphotoxin-Sc1a (Kappa-TRTX-Sc1a) (Stromatoxin-1) (ScTx1)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider