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Peptide record

TPDB29585

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB29585
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCLGWFKGCDPDNDKCCEGYKCNRRDKWCKYKLW
Physicochemical Analysis
C182H267N51O51S6
AQHIMSTV
CK
4177.79
8.01
8
6
8
+2
5.93
-1.268
22.94
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
19855
475.25
10
Residue Composition
number
0
A
2
R
2
N
5
D
6
C
1
E
0
Q
3
G
0
H
0
I
2
L
6
K
0
M
1
F
1
P
0
S
0
T
3
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 5 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 6 M: 0 F: 1 P: 1 S: 0 T: 0 W: 3 Y: 2 V: 0
Chemical Descriptors
34
C182H267N51O51S6
4177.79
8.01
+2
5.93
-1.268
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent voltage-gated sodium channel blocker (IC(50)=190 nM and 210 nM on human and rat Nav1.3/SCN3A respectively, 430 nM on human Nav1.7/SCN9A, 770 nM and 290 nM on human and rat Nav1.8/SCN10A, respectively) (By similarity). Binds the voltage-sensor domain of the potassium channel KvAP (from Aeropyrum pernix) and weakly inhibits this channel (PubMed:15287735). {ECO:0000250|UniProtKB:P0DL74, ECO:0000269|PubMed:15287735}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Potent voltage-gated sodium channel blocker (IC(50)=190 nM and 210 nM on human and rat Nav1.3/SCN3A respectively, 430 nM on human Nav1.7/SCN9A, 770 nM and 290 nM on human and rat Nav1.8/SCN10A, respectively) (By similarity). Binds the voltage-sensor domain of the potassium channel KvAP (from Aeropyrum pernix) and weakly inhibits this channel (PubMed:15287735)..
Voltage sensor toxin 3 (VSTX3) (Beta/kappa-theraphotoxin-Gr4a) (Beta/kappa-TRTX-Gr4a)
spider
Neurotoxin 10 (Hwtx-1) family, 61 (VSTX3) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15287735}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Potent voltage-gated sodium channel blocker (IC(50)=190 nM and 210 nM on human and rat Nav1.3/SCN3A respectively, 430 nM on human Nav1.7/SCN9A, 770 nM and 290 nM on human and rat Nav1.8/SCN10A respectively) (PubMed:24211312). Binds the voltage-sensor domain of the potassium channel KvAP (from Aeropyrum pernix) and weakly inhibits this channel (By similarity). {ECO:0000250|UniProtKB:P0C2P5, ECO:0000269|PubMed:24211312}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Potent voltage-gated sodium channel blocker (IC(50)=190 nM and 210 nM on human and rat Nav1.3/SCN3A respectively, 430 nM on human Nav1.7/SCN9A, 770 nM and 290 nM on human and rat Nav1.8/SCN10A respectively) (PubMed:24211312). Binds the voltage-sensor domain of the potassium channel KvAP (from Aeropyrum pernix) and weakly inhibits this channel (By similarity)..
Voltage sensor toxin 3 (VSTX3) (Beta/kappa-theraphotoxin-Gr4a) (Beta/kappa-TRTX-Gr4a)
spider
Neurotoxin 10 (Hwtx-1) family, 61 (VSTX3) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24211312}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 61 (VSTX3) subfamily
Voltage sensor toxin 3 (VSTX3) (Beta/kappa-theraphotoxin-Gr4a) (Beta/kappa-TRTX-Gr4a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15287735}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:24211312}.
spider