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Peptide record

TPDB29580

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB29580
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCLGFLWKCNPSNDKCCRPNLVCSRKDKWCKYQI
Physicochemical Analysis
C176H275N51O48S6
AEHMT
C
4065.79
8.58
7
3
9
+4
4.14
-0.688
54.41
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
12865
316.42
13
Residue Composition
number
0
A
2
R
3
N
3
D
6
C
0
E
1
Q
1
G
0
H
1
I
3
L
5
K
0
M
1
F
2
P
2
S
0
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 3 C: 6 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 2 S: 2 T: 0 W: 2 Y: 1 V: 1
Chemical Descriptors
34
C176H275N51O48S6
4065.79
8.58
+4
4.14
-0.688
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent inhibitor of Nav1.2/SCN2A voltage-gated sodium channels (IC(50)=0.6-0.7 nM) (PubMed:16267209, PubMed:29703751). Also weakly inhibits Nav1.1/SCN1A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.7/SCN9A and Nav1.8/SCN10A (IC(50)=20-610 nM) (PubMed:16267209, PubMed:29703751). It acts by shifting the voltage dependence of channel activation to more depolarized potentials and by blocking the inward component of the sodium current (PubMed:16267209). It shows low affinity for lipid bilayers (PubMed:29703751). In vivo, this toxin causes general ataxia, lack of response to stimuli, and semiparalysis (PubMed:16267209). After a few minutes, the mice are unable to stand, and breathing is reduced in rhythm and intensity (PubMed:16267209). Symptoms gradually increase with progressive slowing of breathing and flaccid paralysis death occurred within 10 to 20 minutes post injection (PubMed:16267209). Animals remain totally flaccid, and no symptoms of excitatory neurotoxicity are observed (PubMed:16267209). {ECO:0000269|PubMed:16267209, ECO:0000269|PubMed:29703751}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Potent inhibitor of Nav1.2/SCN2A voltage-gated sodium channels (IC(50)=0.6-0.7 nM) (PubMed:16267209, PubMed:29703751). Also weakly inhibits Nav1.1/SCN1A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.7/SCN9A and Nav1.8/SCN10A (IC(50)=20-610 nM) (PubMed:16267209, PubMed:29703751).
Beta-theraphotoxin-Ps1a (Beta-TRTX-Ps1a) (PaurTx-III) (Phrixotoxin-3) (PaurTx3)
spider
Neurotoxin 10 (Hwtx-1) family, 08 (Gtx1-15) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16267209}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 08 (Gtx1-15) subfamily
Beta-theraphotoxin-Ps1a (Beta-TRTX-Ps1a) (PaurTx-III) (Phrixotoxin-3) (PaurTx3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:16267209}.
spider