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Peptide record

TPDB29568

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB29568
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCIPGGENCDVFRPYRCCSGYCILLLCA
Physicochemical Analysis
C131H203N35O39S6
QHKMTW
C
3084.62
4.31
2
3
10
-1
0.73
0.479
83.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
3355
108.77
10
Residue Composition
number
1
A
2
R
1
N
2
D
6
C
1
E
0
Q
3
G
0
H
2
I
3
L
0
K
0
M
1
F
2
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 3 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
28
C131H203N35O39S6
3084.62
4.31
-1
0.73
0.479
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May inhibit sodium (Nav) or calcium channels (Cav).

Target

voltage-gated sodium channel (Nav) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conasprella delessertii (Sozon's cone) (Conus delessertii)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
May inhibit sodium (Nav) or calcium channels (Cav).
Conotoxin de7b
cone snail
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin de7b
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail