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Peptide record

TPDB29531

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB29531
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCCYGRVNGCNPKMADKNYE
Physicochemical Analysis
C92H142N28O32S4
QHILFSTW
NC
2280.55
6.18
3
3
5
-0
6.07
-1.145
19.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
3105
136.15
8
Residue Composition
number
1
A
1
R
3
N
2
D
3
C
1
E
0
Q
2
G
0
H
0
I
0
L
2
K
1
M
0
F
1
P
0
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 2 C: 3 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 2 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
20
C92H142N28O32S4
2280.55
6.18
-0
6.07
-1.145
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Heterodimer: presynaptic neurotoxin. FUNCTION: Monomer: Snake venom phospholipase A2 (PLA2) is inactive towards micellar phosphatidylcholine but is weakly active towards non-micellar dithiolecithin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pseudocerastes fieldi (Field's horned viper) (Pseudocerastes persicus fieldi)
Neurotoxin Presynaptic neurotoxin
Heterodimer: presynaptic neurotoxin. FUNCTION: Monomer: Snake venom phospholipase A2 (PLA2) is inactive towards micellar phosphatidylcholine but is weakly active towards non-micellar dithiolecithin. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Acidic phospholipase A2 CbIbeta (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
snake
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydrolase Neurotoxin Presynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Hydrolase Neurotoxin Presynaptic neurotoxin Secreted Toxin
Neurotoxin Presynaptic neurotoxin
Evidence at protein level
Phospholipase A2 family, Group II subfamily, D49 sub-subfamily
Acidic phospholipase A2 CbIbeta (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake